Özet:

Objectives: This study's aim is to investigate if using thiol/disulphide homeostasis parameters which are oxidative stress markers together with Neutrophile-Lymphocyte and Platelet-Lymphocyte ratio (NLR, PLR) is diagnostically useful in the patients who present to the emergency department with renal colic. Materials and Methods: The study was made prospectively with 75 patients who were admitted to the emergency department between 15.05.2018 and 01.10.2018 and 47 healthy subjects who were determined as control group. Thiol/disulphide homeostasis parameters (thiol, disulphide, disulphide / native thiol, disulphide / total thiol, native thiol / total thiol) which are oxidative stress markers are measured by a new method which was developed by Erel and Neşelioğlu in the patient and control groups, also NLR and PLR were studied. These parameters were compared also between the patient groups with urinary stone disease and that without. Results: NLR, PLR, disulphide, disulphide /native thiol and disulphide /total thiol average values were found significantly high (respectively p= 0.010, <0.001, <0.001, <0.001, 0.023, 0.012), but native thiol and total thiol average values were found significantly low (respectively p=0.018 and 0.001) in the patient group. Disulphide, disulphide /native thiol, NLR and PLR average values were found significantly high (respectively p <0.001, <0.001, <0.001, <0.001) in the patient group. Conclusion: Using NLR and PLR in renal colic diagnosis together with thiol/disulphide homeostasis parameters is useful for these patients to make a diagnosis.

Anahtar Kelimeler: