Özet:

Immunglobulin (Ig)- A vasculitis is seen more common in children characterized with benign course, whereas adult-onset form is relatively rare but may be associated with severe organ involvement and worse prognosis. Our aim in this study is to retrospectively evaluate clinical features, detailed analysis of renal involvement, longterm renal outcome and overall prognosis in adult-onset IgA vasculitis patients followed in our center. 52 cases fullfilling selection criterias were included in this study. Majority of patients were male (37 vs 15, 71,2% vs 28.8%) and mean age was calculated 45 ± 18 years. Among 20 patients who had renal involvement, renal biopsy was performed in 12 (23,1%), consistent with IgA nephropathy. Chronic kidney disease (CKD) developed in 5, and among those, hemodialysis was needed in 3 at least once through entire following period. Relaps was seen in 9 (17,3%) with the sites of distribution as following; 5 renal, 3 skin and 1 gastrointestinal. Acute kidney injury (50% vs 10% p:0,002) and nephrotic range proteinuria (75% vs 32,5% p:0,028) at admission were found significantly higher in patients at advanced age (>65). CKD development (33,3% vs 2,5%, p<0,001) and overall mortality were also higher (41,7% vs 5% p:0,001) in this group. Mortality was seen in 7 patients and 71,4% of them had acute kidney injury at the time of first admission (p<0,001). In our study, we have found that advanced age (>65) and renal involvement seem to be significant risk factors for the development of CKD and overall mortality, consistent with the literature. Therefore, these patients should be monitored closely.

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