Özet:

Introduction: Tramadol, as a centrally acting synthetic analgesic agent, shows its effects by multiple transmitter systems. Tramadol usage may cause respiratory depression, seizures, renal failure. Alprazolam is a triazolobenzodiazepin derivative agent that has anxiolytic and antidepressant effects. High dose usage can cause side effects such as light-headedness, drowsiness, respiratory depression, delirium, coma, and death.Case Report: In this case report, we represent a 58-year-old male patient admitted to Emergency Department with altered mental status and acute renal failure after co-ingestion of tramadol and alprazolam. With supportive mechanical ventilation and hemodialysis he was discharged with fully remission on the ninth day of follow-up.Conclusion: Clinicians should be aware of cases presented with altered mental status and kidney failure associated with tramadol and alprazolam usage

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