Abstract:

Clostridioides difficile infection (CDI) represents the most common cause of diarrheic disease associated to public health services, an important public health problem due to the potential risk of complications, severe forms of pseudomembranous colitis and death. Although the great majority of CDI patients have a favourable response to specific antibiotic drug therapy, a significant percentage will present one or several relapses and the risk of relapse increases with the increase in numbers of infectious episodes, reaching 50-60% after the third CDI episode. Faecal microbiota transplant (FMT) is a proven effective treatment method with high rates of curability in recurrent and refractory CDI. However, can we use FMT earlier than the current recommendations of the treatment guidelines? The evidence is beginning to pile up.

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