Abstract:

tion: Heterocyclic compound quinoline, a very important category of heterocyclic compounds, and its derivatives have medicine properties. Quinoline contains element heterocyclic aromatic ring. It’s additionally referred to as benzopyridine or 1-aza-napthalene and chemical formula of quinoline is chemical formula C9H7N. Methods: Synthesis of quinoline derivative from 4-Methoxy-acetophenon and 1H-Indole-2,3-dione after that reaction between 2-(4-Methoxy-phenyl)-quinoline-4-carboxylic acid and using excess of dry methanol in the presence con. H2SO4 for the synthesis of 2-(4-Methoxy-phenyl)-quinoline-4-carboxylic acid methyl ester and this intermediate product react with hydrazine hydrate in methanol and 2-(4-Methoxy-phenyl)-quinoline-4-carboxylic acid hydrazide derivative collated and react with five deferent substituted acetophenone. Five quinoline derivatives were synthesis and were synthesis, characterization and evaluated antimicrobial activity against standard drug. Results: Some new substituted quinoline derivative 2-(4-Methoxy-phenyl)-quinoline-4-carboxylic acid (1-phenyl-ethylidene) hydrazide (M1), 2-(4-Methoxy-phenyl)-quinoline-4-carboxylic acid [1-(4-amino-phenyl)-ethylidene]-hydrazide (M2), 2-(4-Methoxy-phenyl)-quinoline-4-carboxylic acid [1-(4-bromo-phenyl)-ethylidene] hydrazide (M3), 2-(4-Methoxy-phenyl)-quinoline-4-carboxylic acid [1-(4-chloro-phenyl)-ethylidene]-hydrazide (M4) and 2-(4-Methoxy-phenyl)-quinoline-4-carboxylic acid [1-(4-hydroxyphenyl)ethylidene]-hydrazide (M5). All derivatives were found the active against different microorganism. Some compounds show the good antifungal activity. Conclusion: Some new substituted quinoline derivative synthesis and evaluated antimicrobial activity against the Gram-positive and Gram-negative bacterial stain and fungal stain. All derivatives were shown the antimicrobial activity.

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