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Çin'de başlayan ve pek çok ülkeye yayılan Covid-19, ‘Koronavirüs Pandemisi’ olarak dünya çapında bütün insanlığı tehdit eden bir salgın hastalık haline gelmiştir. Virüsün insandan insana hızlıca bulaşması ve yüksek ölüm oranına sahip olması, standart terapi protokollerinin geliştirilmesi ve onaylanması için acil bir ihtiyaç ortaya çıkarmıştır. Etkili tedavi stratejilerinin geliştirilebilmesi için; virüsün yapısal özellikleri, biyolojisi ve konak hücredeki enfeksiyon mekanizmaları tam olarak bilinmelidir. Şimdiye kadar, Kovid-19'un tam bir etkili tedavisi bilinmemekle birlikte, olası antiviral ilaçların klinik deneme ve değerlendirmeleri devam etmektedir. Tıbbi bitkiler glikozitler, saponinler, flavonoidler, proantosiyanidinler, terpenoidler, fenil propanoidler, tanenler, reçineler, lignanlar, sülfitler, polifenolikler, kumarinler, furil bileşikleri, alkaloidler ve uçucu yağlar olmak üzere çok çeşitli aktif fitokimyasal bileşikler ihtiva ettiklerinden dolayı pek çok hastalıkta olduğu gibi viral kaynaklı hastalıklarda da konakçının bağışıklık sistemini güçlendirerek antiviral etki göstermektedir. Yaygın olarak kullanılan bazı yenilebilir yabani bitkilerin, baharatların ve bitkisel çayların çeşitli virüslere karşı güçlü antiviral aktivite gösterdikleri dahası, bunlardan bazılarının farklı tür koronavirüs kaynaklı hastalıklarda da kullanılma potansiyelinde olan fito-antiviral ajanlar oldukları önceki çalışmalarda ortaya konulmuştur. Bu derlemede ise; bağışıklık sistemini güçlendirici, hastalıklara karşı koruyucu ve tedavi edici olarak Türkiye’de geleneksel kullanıma sahip olan laden türleri (Cistus spp.), bazı kekik türleri (Origanum, Thymus ve Thymbra), meyan kökü (Glycyrrhiza glabra L.) ve zeytin yaprağı (Olea europea L.) bitki türleri ve bunlardan elde edilecek biyoaktif bileşiklerin koronavirüs enfeksiyonları ile mücadelede bitkisel kaynaklı doğal terapötikler olarak kullanılma potansiyelleri güncel literatür bilgileri ışığında sunulmuştur.
Covid-19, emerging in China and spreading to many countries, has become an epidemic disease that threatens all humanity worldwide as 'Coronavirus Pandemic'. The rapid transmission of the virus from person to person and its high mortality rate create an urgent need for the development and validation of standard therapy protocols. In order to develop efficient treatment strategies, the structural features, the biology of the virus and the mechanisms of infection in the host cell must be fully known. So far, the exact effective treatment of Covid-19 has not been revealed, but clinical trials and evaluations of possible antiviral drugs are ongoing. Since medicinal plants have a wide variety of bioactive phytochemical compounds such as glycosides, saponins, flavonoids, proanthocyanidins, terpenoids, phenylpropanoids, tannins, resins, lignanes, sulfides, polyphenolics, coumarins, furyl compounds, alkaloids and essential oils, they exhibit antiviral effects by strengthening the immune system of the host in diseases of viral origin, as well as they are useful for many diseases. Previous scientific studies showed that commonly used wild edible plants, spices and herbal teas possess strong antiviral activities against various viruses; moreover, some of them have also been proven to be used for different types of coronavirus-original diseases as potential phyto-antiviral agents. In this review, having traditional medicinal uses in Turkey, some medicinal plants like cistus species (Cistus spp.), some grape species (Origanum, Thymus and Thymbra), liquorice root (Glycyrrhiza glabra L.), olive leaf (Olea europea L.) and their bioactive compounds, which are immune enhancer, preventive and therapeutic against diseases as potential natural therapeutics for fighting coronavirus infections have been presented in the light of current scientific literature.
Covid-19, emerging in China and spreading to many countries, has become an epidemic disease that threatens all humanity worldwide as 'Coronavirus Pandemic'. The rapid transmission of the virus from person to person and its high mortality rate create an urgent need for development and validation of standard therapy protocols. In order to develop efficient treatment strategies, the structural features, biology of the virus and the mechanisms of infection in the host cell must be fully known. So far, the exact effective treatment of Covid-19 has not been revealed, but clinical trials and evaluations of possible antiviral drugs are ongoing. Since medicinal plants have a wide variety of bioactive phytochemical compounds such as glycosides, saponins, flavonoids, proanthocyanidins, terpenoids, phenylpropanoids, tannins, resins, lignanes, sulfides, polyphenolics, coumarins, furyl compounds, alkaloids and essential oils, they exhibit antiviral effects by strengthening the immune system of the host in diseases of viral origin, as well as they are useful for many diseases. Previous scientific studies showed that commonly used wild edible plants, spices and herbal teas possess strong antiviral activities against various viruses; moreover, some of them have also been proven to be used for different types of coronavirus-origine diseases as potential phyto-antiviral agents. In this review, having traditional medicinal uses in Turkey, some medicinal plants like cistus species (Cistus spp.), some kekik species (Origanum, Thymus and Thymbra), liquorice root (Glycyrrhiza glabra L.), olive leaf (Olea europea L.) and their bioactive compounds, which are immune enhancer, preventive and therapeutic against diseases as potential natural therapeutics for combatting coronavirus infections have been presented in the light of currents scientific literature.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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