Abstract:

The purpose of this study was to develop formulations and systematically evaluate in vitro performances of the super porous hydrogel of Venlafaxine HCl. Venlafaxine Hydrochloride-based Hydrogels were prepared by using a factorial design. A 3-factor three-level Box–Behnken design was employed to study the effect of independent variables on dependent variables. The selected independent variables considered were the concentration of HPMC K4M (g) (X1); HPMC K100M (g) (X2); and Stirring time (seconds) (X3). Mechanical strength, Porosity, and Dissolution were selected as the dependent variables. FT-IR spectra revealed that there was no variation in the properties of the drug and polymers in the formulation. The response Mechanical strength and Porosity followed interactive (3FI) model and the summary of Analysis of variance (ANOVA) and Optimization was performed with constraints of Mechanical strength in the range of 130 – 1000 g/sq.cm, Q4h in the range of 35-55%, and Q8h in the range of 65 - 90%, to get optimized formula solutions with higher desirability function.

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