Özet:

Purpose: Invasive breast carcinomas are malignities that are common in women in our country, as well as in the world, and cause death. The cause of death from breast cancer is usually metastasis. Determination of the potential of the tumor to metastatise is an important factor in the direction of treatment. The assessment of lymphatic spread in the tumor is especially useful in predicting the risk of metastasis. Since the retraction artefacts phenomenon can be seen in the early stages of lymphatic spread, it can be a prognostic value, it can predict the possibility of lymphatic spread and metastasis. In our study we also studied the relationship between the retraction artefacts and other clinic pathological parameters, lymphovascular invasion and nodal metastasis. Material and Method: In our study, a total of 191 facts diagnosed with invasive duktal carcinoma from modified radical mastectomy materials between 2010 and 2015 were studied retrospective. The presence of retraction artefacts for the tumor tissue of the whole painted cuts of Hematoxylene Eozin (HE) was classified by 4 points. 2+ and it was accepted meaningfully. Results: In 45 cases (23.6% of cases) there was no retroaction artefacts. In 51 (%26.7) +1, 57 (%29.8) +2, 36 (%18.8) +3 and 2 (%1) +4 are detected retroaction artefacts. 76 (65%) of the 95 incidents identified with retraction artefacts have been traced with lymphovascular invasion. In 68 of 113 nodal metastases (60.2%), there is a retraction artefacts. The result: a positive correlation between the presence of the retraction artefacts and the histological degree, the presence of in situ carcinoma, the tumor stage, the lymphovascular invasion and the metastasis of the lymph nodes has been established. In breast cancer, the relation of lymphangiogenesis with the retroaction artefacts is meaningful. But our findings must be supported by molecular studies.