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Synthesis of Some Hydrazone Derivatives Bearing Purine Moiety as Anticancer Agents
2014
Journal:  
The Turkish Journal of Pharmaceutical Sciences
Author:  
Abstract:

In the present study, some hydrazone derivatives were synthesized via the reaction of 6-hydrazino-9-(P-D-ribofuranosyl)-9H-purine with various benzaldehydes. The structures of the compounds were elucidated by spectroscopic tecliniques such as H-NMR. 13C-NMR and ES-MS and elemental analyses. Anti-prolif-erative activity tests were perfonned on human lung (A549) and breast (MCF-7) cancer celi lines using MTT assay. Some derivatives were found to be effective against A549 and MCF-7 celi lines ainong these compounds. They exhibited time and dose dependent anti-proliferative activity against A549 and MCF-7 cancer celi lines.

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The Turkish Journal of Pharmaceutical Sciences

Field :   Sağlık Bilimleri

Journal Type :   Uluslararası

Metrics
Article : 226
Cite : 48
2023 Impact : 0.051
Details
The Turkish Journal of Pharmaceutical Sciences