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Purpose: The cumulative antibiotic sensitivity reports can guide the right choice of empiric therapy and the development of anti-antibiotic resistance policies. This study aims to prepare a one-year cumulative antibiotic sensitivity report for gram-negative and gram-positive factors, isolated from clinical samples of patients in our hospital. Method: Detection of bacteria and antibiotic sensitivity were tested automatically with the VITEK 2 (bioMérieux, France) system and antibiotic results were evaluated according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST, 2021) recommendations. The cumulative antibiotic sensitivity report is prepared according to the criteria set out in the Guidelines for Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data (CLSI 2014, M39-A4). This study included 1, 490 insulates. The most effective antibiotics for gram-positive bacteria were vancomycin, thyroplanin, linezolid and tigesiclin. In addition to these antibiotics, tetrasiclin is Enterococcus spp. It is effective in isolation. While tigesiclin and sefuroxim in the Escherichia coli isolates of enteric bacteria are effective, it has been found that nitrofurantoin and meropenamine in the urine enteric E. coli isolates can be used in ampiric treatment. The most effective antibiotics against Proteus mirabilis have been found to be meropenem and amikasin. In enteric and urine enteric bacteria, there has been no preferred antibiotic option in the Klebsiella pneumoniae isolates for ampiric treatment. The most effective antibiotic in acinetobacter baumannii is tigesiclin, while the most effective antibiotic in Pseudomonas aeruginosa is tobramine. The ampiric treatment options for gram-negative and gram-positive bacteria are quite limited, and we believe that closely monitoring of cumulative antibiotic reports will improve and reduce antibiotic resistance rates.

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