Abstract:

Primary dysmenorrhea is uterine cramping that occurs during or before menstruation without pelvic disease and causes suprapubic pain. In researching the causes of dysmenorrhea, several studies have highlighted the role of lacking vitamin D (vit D). Vit D acts by suppressing the synthesis of prostaglandins that cause pain. Our study aims to investigate whether vit D level affects primary dysmenorrhea. For this purpose, vit D 3 level will be studied in patients with primary dysmenorrhea and a control group without dysmenorrhea. This retrospective, randomized, case-controlled study was conducted between January 2020 and August 2021 at two different centers. It was approved by the ethics committee. Information was obtained by interviewing eligible subjects for the study, and informed consent was obtained. 750 women presented to the gynecology departments of the participating centers involved in the study. Ages between 16-35 are included in the study. Under 18 patients were referred from pediatric clinics with similar symptoms. 325 women were assigned to the dysmenorrhea group. All patients had a regular menstrual cycle and pain that began the day before menstruation. 325 patients unrelated to dysmenorrhea were selected randomly as a control group. The participants in our study were randomly selected into the dysmenorrhea group and the control group, and their clinical characteristics were compared in Tables 1 and 2. Significance was remarkable comparing the dysmenorrhea patients with the healthy control groups. That dysmenorrhea patients with 25-hydroxyvitamin D3 deficiency had significantly less consumption of dairy products. VAS values were higher, and undereducation and unemployment were also significantly more common. Low serum vit D levels and dysmenorrhea are strongly related. It is obvious that there is a significant relationship between vit D levels, VAS score, and primary dysmenorrhea. More studies at larger scales are needed to underline the efficiency of vit D in primary dysmenorrhea.

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