Özet:

The aim of this study was to evaluate the effects of Midazolam-Ketamine-Isoflorane (MRI) and Midazolam-Propofol-Isoflorane (MPI) anesthesia on coagulation parameters, vital parameters, hemogram parameters, blood gas parameters and biochemical parameters.             The study was held on varying breed, race and gendered total 20 dogs aging between 4 months to 6 years that were brought for various reasons taken under surgical intervention to Afyon Kocatepe University animal hospital. Dogs were randomly grouped as MKI (n=10) and MPI (n=10). MKI and MPI groups dogs were premedicated with midazolam 0.2-0.4 mg/kg intravenously following fasting period for 12 hours. MKI group anesthesia were induced by the injection of ketamine 15mg/kg and in MPI group by the slow injection of propofol 6-7mg/kg by i.v. Both group dogs were intubated with endotracheal tube and general anaesthesi was achieved by Isoflurane 2%.             Blood samples were collected from all group dogs at 0th, 15.th And 30th minutes and postoperatively 0th min. and 6th hour for the measurement of hemogram blood gases and coagulation parameters together with the collection of vital parameters.                When the groups were compared, preoperative 0th minute measurements PT, TT fibrinogen and APTT values were insinificantly changed statistically (p>0.05). All the time period measurements were found between normal values. Within the results of measurements, both anesthesia protocol was found safe and convenient in the use of dogs' anesthesia for the average of coagulation parameters, vital parameters, blood gas parameters hemogram parameters and biochemical parameters.

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