Özet:

Purpose: Metabolic disorders that occur in postmenopausal period increase the risk of developing fat liver disease in women. The aim of this study is to evaluate the effects of ghrelin on metabolic biobeliracts and hepatic morphology in overectomized (OVTs) rats. The tool and method: under anesthesia of ketamine-chlorpromazine (100 mg / kg, 0.75 mg / kg), double-sided OVT was applied to Sprague-Dawley rats (n = 12), simulation surgery was applied in the control group (n = 6). Four weeks after the operation, half of OVT rats were treated orally with ghrelin (1 mg / kg / week) for 4 weeks, the rest were not treated. and 8. Serum glucose, insulin, aspartate aminotransferase (AST), high-intensity lipoprotein (HDL), low-intensity lipoprotein (LDL), very low-intensity lipoprotein (VLDL), triglycerides, estradiol and progesterone, are measured by an automatic analyst. Results: The body weight increased with OVT at the end of 2 months (p <0,001) did not change with grelin. Serum estradiol and progesterone levels have decreased in such a way as to confirm the condition of the altered gonadal hormone (p <0,05), but the levels of insulin and glucose have not changed. Decreased HDL and increased LDL levels (p <0,05) were manifested in untreated OVT rats, the treatment of grelin lowered LDL levels (p <0,05), but did not change HDL levels. However, OVT significantly reduced the levels of ghrelin, triglycerides, VLDL and AST in rats (p <0,05). The sinusoidal conjunction in the OVT group, activated Kupfer cells and damaged hepatosites in the form of ballonization, was observed by the treatment of grelin. The result is that in the early postmenopausal period, mild dyslipidemia and liver degeneration are reduced with the treatment of ghrelin, and the study requires more research.