Özet:

The aim of the study. Analyze the content of some bioelements and cumulative properties of heavy metal ions (on an example of cadmium) for nitrate intoxication. Materials and methods. The object of the study was white rats, which were divided into two groups: I-control, II-research (receiving aqueous NaNO3 solution with drinking water at a dose of 1/10 DL50). Intoxication was carried out for 10 days. The material was collected (renal tissue, liver and spleen) on 1st, 14th and 28th days after the completion of the administration of the toxicant. The level of macro- and micronutrients was determined by the atomic absorption spectrophotometer C-115PK. The obtained results were statistically processed using the computer program Statistics. Results. Under the influence of NaNO3, an increase in the calcium level in the renal tissue, liver and spleen was noted compared with the control group of animals. At the same time, the Mg content in the liver was declined throughout the observation period, whereas in the kidneys and spleen - on the first day of the experiment. The research of essential trace elements, such as Zn and Cu, allowed to establish the following changes: enhance of Zn level in the liver оn the 1st and 14th day and its decrease on the 28th day; in the renal tissue and spleen the value of this index was increased on the 28th day in comparison with the control group of animals. The content of Cu was increased on the 28th day in the spleen and liver, whereas in the renal tissue the value of this index was lower than the control group values. Te analysis of the cadmium level showed that Cd content in the spleen, the liver and the renal tissue of the animals after influence of NaNO3 exceeded the control values in 3-3,8 times. Conclusions. It was established that the organisms of experimental animals under the condition of nitrate intoxicationare characterizes by the development of dysmicroelementosis, which is featured by the changes in the levels of vital macro- and trace elements in organs and tissues, which is important for the regulation of metabolic processes. An increase in the ability of cadmium ions to accumulate in the studied organs and tissues is also shown Author Biographies Larisa Nechytaylo, Ivano-Frankivsk National Medical University Halytska str., 2, Ivano-Frankivsk, Ukraine, 76018 Assistant The department of Biological and Medical Chemistry

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