Abstract:

Objective: The aim of this study is to assess the factors that affect IVF success in women of critical ages of “38-40 years”. Method: 468 women aged 38-40 years who were admitted for IVF  between January 2013 to December 2017 were enrolled in the study. Ovarian stimulation characteristics, number of oocytes retrieved, number of embryos transferred and pregnancy rates ,cancellation rate ,live birth rate were analyzed. Results: The overall clinical pregnancy rate was 17.9% . Cancellation rate was 22.4%. The miscarriage rate was 25% (21/84).The live birth rate was 13.4% (63/468).Comparing the patients who did and did not achieve conception, we found statistically meaningful differences in terms of antral follicular count, retrieved oocyte count, number of embryos obtained, embryo count that was transferred,. Logistic regression analysis showed that the following factors were significantly related to higher pregnancy rates: number of embryos transferred, HMG usage in the stimulation protocol, basal FSH and blastocyst transfer.  Conclusions: The most important parameters which predict pregnancy in 38-40 year-old women are the transfer of a high number of embryos, HMG usage in the stimulation protocol, low basal FSH level and blastocyst transfer.   

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