Özet:

Adenocarcinoma of the prostate is the most common malignant neoplasm of the organ, which, from architectural point of view, is represented by small, large, fused glands and solid type. A common problem of differential diagnosis of small glands adenocarcinoma is represented by sclerosing adenosis, a pseudoneplasic lesion. Differentiation of these two entities is based, in addition to architectural and immunohistochemical features, on the nuclear changes in prostatic epithelial cells. In this study we aimed to assess nuclear morphometric features of epithelial cells in sclerosing adenosis (33 cases) compared with cases diagnosed with Gleason grade 1 and 2 adenocarcinoma (69 cases). Parameters evaluated were represented by the nuclear area, perimeter, maximum diameter, minimum diameter, mean diameter and elongation. Morphometric analysis revealed significantly higher values of nuclear parameters in adenocarcinomas compared with sclerosing adenosis cases (p <0.05). In conclusion, nuclear morphometry, proved useful in the discrimination of the two histopathological entities.

Anahtar Kelimeler: