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Introduction: The Indonesian government's efforts to deal with the COVID-19 pandemic are implementing a Large-Scale Social Restriction (LSSR) policy. This LSSR policy becomes a problem for the quality of life of the people who carry out the policy, including college students and students. This research aims to determine the quality of life of college students and students in Indonesia who undergo LSSR during the COVID-19 pandemic. Methods: This research is a descriptive study with a cross-sectional approach. This research used accidental sampling methods by 30 days of distributing e-questionnaires. The samples used in this study were college students and students who were undergoing the LSSR in Indonesia. The instrument used for this research was WHOQOL-BREF. The quality of life was analyzed descriptively by calculating each domain's average transformed score. Results: Through this research, obtained 280 respondents consisting of 67 men and 213 women. Respondents aged 12-17 years were nine respondents, and 18-25 years were 271 respondents. The majority of respondents underwent LSSR for 9-12 weeks. Analysis of quality of life showed that the physical health domain had an average of 62.65 ± 0.87; psychological health of 62.58 ± 1.04; social relations of 53.76 ± 1.16; and the environment 61.53 ± 0.98. Conclusion: The conclusion in this study is that college students and students who undergo PSBB have good physical health, good psychological health, moderate social relationship quality, and good environmental quality.

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