Özet:

Objective: Prostate cancer is usually found in men over the age of 60. The frequency of occurrence under the age of 40 is quite rare and the most common malignant tumors in men are. This is the second most frequent cause of cancer-related death in men after lung cancer. The most common type of histopathology is adenocarcinoma. The exact diagnosis is made by a histopathological examination. The rectal key, radiological imaging and blood test are helpful methods in diagnosis of prostate-specific antigen (PSA). Transuretral prostate resection (TURP) is a surgical method used to patients with PSA values below 4 ng/mL with no clinical malignity suspicion, which is considered to be beneficial prostate hyperplasia (BPH) in front. The purpose of the study is to share random prostate cancer cases in our TURP materials with literature, to contribute to the diagnosis, treatment and tracking of patients. Tools and Methods: The study conducted a retrospective analysis of 1033 TURP materials performed between 2013-2018 in our university hospital. The study included the facts sent to the pathological laboratory with a pre-diagnosis of BPH with a PSA level below 4 ng/mL, which was not previously diagnosed with cancer. Cuts taken from the paraffin blocks of the cases were studied by painting hematoxylene-eosine. Since prostate adenocarcinomas have a basal layer loss, cases of atypical small asiner structures have been re-evaluated by applying P63 and high molecular weight cytokeratine (HMWCK) immunohistochemical study that indicates the basal layer. Results: As a result of the histopathological examination, random prostate adenocarcinoma was detected in 13 (1.25%) of 1033 incidents that had no clinical malignity suspicion. In cases of cancer diagnosed, 1 to 20% of tumor tissues were present. In these cases, an average of 8% of tumor tissues were found. The result: in prostate cancer, the full TURP materials must be monitored and examined to correctly calculate the tumor volume and diagnosis. The presence of small asiner structures that suspect cancer will contribute to the reduction of the error rate in the diagnosis, along with immunohistochemical markers.

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