Özet:

The aim of the work. To analyze the physicochemical and biopharmaceutical properties of meglumine (MGA), to generalize and systematize the data for its functional use in the development of drugs with prescribed pharmacological and technological parameters. Materials and Methods. Methods of system approach, bibliographic, information search, analysis, comparison and generalization are used. Results and Discussion. The analysis and generalization of literature and information data on physicochemical and biopharmaceutical properties is carried out MGA and its salts.Due to the characteristic features of the molecular structure, which is characterized by the presence of five hydroxyl groups and a secondary amino group, MGA exhibits salt-forming, solubilizing and stabilizing properties. The biopharmaceutical effects of MGA are due to the ability to form stable complexes of amino alcohol with cell membrane proteins, which reduces the effect of osmotic shock on the cell, reduce the toxicity of drugs. Literature data indicate the formation of real triple complexes of MGA with sulfamerazine and cyclodestrins, which leads to improved dissolution drugs and the release of active pharmaceutical ingredients (APhI) from liposomal compositions. The pharmacokinetic parameters of MGA salts with poorly soluble APIs, such as acridinoacetic, alpha-lipoic, enolic, gadotheric acids and their derivatives, prove the advantages of meglumine-containing compounds, which increase the solubility and bioavailability of APhIs. Of particular relevance is the use of IHA to model the required pharmacological and technological parameters of solid dosage forms having fixed combinations of API with different solubility parameters. Conclusions. The generalization of the literature data indicates that IHA has unique physicochemical and biopharmaceutical properties, which open up prospects for the use of this compound for the development of drugs with specified pharmacological and technological characteristics.

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