Özet:

Background and Aims: High serum D-dimer level associates with prognosis in patients with breast and colorectal cancer. The prognostic value of serum D-dimer level in gastric cancer is unclear. In this study, we evaluated the prognostic value of D-dimer level in gastric cancer. Materials and Methods: The patients' data were retrospectively obtained from the hospital records. The demographic parameters and pathological findings of the patients were recorded. Serum carcinoembryonic antigen and D-dimer levels at the time of diagnosis were categorized as normal or high. Results: A total of 44 patients were included in our study. At the time of diagnosis, the median carcinoembryonic antigen and D-dimer levels were 2.1 ng/dl (0.45-201) and 358 ng/dl (130-7361), respectively. High carcinoembryonic antigen was associated with stage and metastatic disease (p=0.001 and p=0.021). There were no associations between serum D-dimer level and sex, T and N status, stage, Eastern Cooperative Oncology Group performance status, or lymphovascular invasion. At the initial diagnosis, high serum D-dimer level was a prognostic factor for survival in patients with gastric cancer, but not serum carcinoembryonic antigen level (p=0.024). Conclusions: Elevated serum D-dimer levels may be a poor prognostic factor in gastric cancer.

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