Özet:

This study was aimed at comparing the values of the average thrombocyte volume (MPV) and red blood cell distribution width (RDW) according to the healthy control group of graves patients and whether they have a relationship with cardiovascular risk factors. 50 graves patients and 50 healthy control patients were examined retrospectively. Diabetes mellitus (DM), iron deficiency anemia, chronic kidney injury, hypertension (HT), previously experienced myocardial infarction, congestive heart failure, chronic inflammatory disease, malignity and patients using antihyperlipidemic drugs were not included in the study. At the time of application of the Healthy Control Group, the MPV and RDW values were recorded in the routine in the full blood count before the diagnosis began. The LDL cholesterol (LDL-C), Hdl cholesterol (HDL-C), triglyceride (TG) values, whether or not smoking, size, weight and body mass index (VKI) files were also retrospective. The comparison of MPV and RDW values with the student-t test, the relationship with cardiovascular risk factors was assessed by the pearson correlation test. NOTE: There is no significant difference between the MPV values of patients with Graves and who have not yet started treatment and the MPV values of the healthy control group (p=0.291). When we look at the RDW values between the two groups, the RDW values of gravels were significantly low compared to the control group (p<0.05). When compared the MPV and RDW values between gravitational female patients and female patients in the control group, the MPV and RDW values of female patients in the control group were significantly higher compared to gravitational female patients (respectively p=0.047, p=0.012). There is no correlation between the cardiovascular risk factors of smoking, age and VKI and MPV, RDW values. The gravitational group did not identify the correlation between LDL-C and RDW, while the negative correlation between LDL-C and MPV was identified (p=0.016, r=-0.443). Results: MPV and RDW values, which are considered as inflammation indicators and cardiovascular disease risk indicators, have not been established a relationship with cardiovascular risk factors in serious patients.

Anahtar Kelimeler:

Özet:

OBJECTIVE: In this study, we aimed to compare mean platelet volume (MPV) and red cell distribution width (RDW) values of graves patients compared to the healthy control group and to determine whether there was a relationship with cardiovascular risk factors. MATERIAL AND METHODS: Fifty graves patients and 50 healthy control patients were evaluated retrospectively. Patients with diabetes mellitus (DM), iron deficiency anemia, chronic kidney injury, hypertension (HT), previous myocardial infarction, congestive heart failure, chronic inflammatory disease, malignancy and using antihyperlipidemic drugs were not included in the study. MPV and RDW values were recorded at the time of admission in the healthy control group and at the time of diagnosis in the graves group before the treatment was started. At the same time, LDL cholesterol (LDL-C), Hdl cholesterol (HDL-C), triglyceride (TG) values, smoking status, height, weight and body mass index (BMI) of both groups were analyzed retrospectively. The comparison of MPV and RDW values was evaluated by student-t test and the relationship with cardiovascular risk factors was evaluated by pearson correlation test. RESULTS: There was no significant difference between MPV values of patients with Graves' disease who had not started medication and MPV values of healthy controls (p = 0.291). When the RDW values between two groups were examined, RDW values of the graves were significantly lower than the control group (p<0.05). When MPV and RDW values were compared between female patients with Graves and female patients in the control group; MPV and RDW values of female patients in the control group were significantly higher than female patients with graves (p = 0.047, p = 0.012, respectively). No correlation was found between smoking, advanced age and BMI and MPV, RDW values that are among Graves' cardiovascular risk factors. There was no correlation between LDL-C and RDW in the Graves group whereas there was a negative correlation between LDL-C and MPV (p = 0.016, r = -0.443). CONCLUSIONS: MPV and RDW values, which are accepted as an indicator of inflammation and cardiovascular disease risk, were not correlated with cardiovascular risk factors in patients with graves.