Nurses are the largest group of employees in the health care sector and play an important role in the delivery of high quality heath care. Unfortunately recent research has indicated that nursing staff in various countries have reported relatively modest levels of work satisfaction. Several countries are facing nursing shortages and the nursing profession has become a less attractive job and career prospect for young women and men. This investigation examines the relationship of six work experiences proposed by Leiter and Maslach (2005) as antidotes to burnout with various work and well-being outcomes in a sample of US nurses (N=289) whose hospitals were undergoing restructuring and budget cuts. The data indicated that high workloads and low levels of reward, control and value congruence were associated with greater nursing staff distress. Suggestions for addressing these job and work experiences are offered along with approaches to implementing restructuring and downsizing processes more likely to contribute to individual and hospital health.