Özet:

Acinetobacter baumannii is an important factor of pneumonia associated with ventilation with the ability to live for a long time in a hospital environment. The increased resistance to the antibiotics that are effective on this pathogen creates anxiety. In this study, the influence of A. baumannii juices that grow in the cultures of endotrekal aspirat (ETA) in intensive care units and the antibiotic resistance profiles and the impact of COVID-19 pandemic on the resistance profiles in our province, where the most vacancies have been seen for a long time. Method and Requirements: Our study included a total of 74 A.baumannii isolates, which were isolated from the ETA samples sent to our laboratory from the Bafra State Hospital’s intensive care units between January 2019 and December 2020. The conventional methods and semi-automatic bacterial detection system used Vitek-2 (bioMérieux, France) isolated A. baumannii juices’ antibiotic sensitivity has been tested with Vitek-2 system in accordance with the European Committee on Antimicrobial Susceptibility Testing (EUCAST) standards. The average age and standard deviations of 18 patients before the COVID-19 pandemic and 56 patients after the pandemic were identified at 83.0 ± 8.3 and 70.5 ± 14.9 (p<0.001) respectively. There was a statistically significant difference between the gender distribution according to the years (p=0.025). In 2019, 55.6 percent of patients were female, while in 2020 73.2 percent were male. Death rates in two periods (p = 0. It is not distinguished in terms of the needs of respiratory support (p=0.191). The number of isolated A. baumannii has increased by 311%. In both periods, the most resistant was piperasilin/tazobaktam, seftazidim, siprofloksacin and imipenema. In both periods, the amikasine resistance has been seen in a lower rate in 2020. A statistically significant difference has been found between the tigesiclin resistance rates over the years (p<0.001). In 2019, the tigesiclin sensitivity of cows was 88.9%, while in 2020 it was 26.8%. In 2019, 11.1 percent of the tumors and 64.3 percent in 2020 were medium-sensitive to tigesikline. In this study, one of all isolates (1.4%) observed collistine resistance, while five isolates (6.6%) observed. 8) The tigesiclin resistance is determined. A isolate (1.4%) was found sensitive to all antibiotics except ceftazidim. 73 In terms of the multi-antibiotic resistance of the A. baumannii isolate, the multi-medicine resistance (CID) was found at 22.9 % (n: 17), the excessive drug resistance (AID) at 74.3 % (n: 55), and the resistance to all medicines (TID) at 1.4 % (n: 1). There was no statistical difference in the resistance of amikasine, meropenem and tigesiclin before and after pandemic, but there was no difference between resistance patterns (p=0.281). The most effective antibiotics against A. baumannii have been found to be colystin and tigesiclin. The COVID-19 pandemic has not changed the rates of resistance fathers. It is believed that each hospital will identify its own resistance patterns, update the protocols of empirical treatment according to its results, and the clinics will be successful in the fight against this infection with the early use of appropriate antibiotics.

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