Abstract:

Purpose: This study aims to determine the effect of mustard greens ethanol extract (Brassica rapa L.) in reducing blood glucose and malondialdehyde levels in hyperglycemic Wistar rats. Methods: The hyperglycemic Wistar rats were divided into 5 groups. Normal groups, positive control group (given glibenclamide) and treatment group were given orally with mustard extract with a dose of dose of 10mg/KgBW, 15 mg/KgBW, and 20 mg/KgBW. Results and Discussion: The ethanol extract of green mustard with a dose of 10, 15, and 20 mg/KgBW reduced 49.60 mg/dl; 74.00 mg/dl; 101.20 mg/dl blood glucose levels, respectively and 6.31 nmol/ml; 6.43 nmol/ml; 7.14 nmol/ml malondialdehyde levels. The phenol groups contained in the extract was hypothesized to be the key for blood glucose levels reduction by the mechanism of capturing or neutralizing the excess free radical in hyperglycemic Wistar rats. Conclusion: One Way ANOVA analysis and Post Hoc Study showed that ethyl acetate fraction of mustard greens extract dose of 10, 15, and 20 mg/KgBW were able to significantly reduce blood glucose and malondialdehyde levels in hyperglycemic Wistar rats (p<0.05).

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