Özet:

Suleyman Demirel University TIP FACULTY JOURNAL: September 2007; 14(3) Tc-99m MIBI breast syntigraphy, mammography and ultrasound methods comparison of the effectiveness of Sevim Süreyya Çerçi*, Celal Çerçi**, Bahattin Baykal***, Mustafa Yıldız*, Feride Meltem Özbek*, F. Nilgün Kapıcıoğlu****, Ahmet Yeşildağ***, Hasan Erol Eroğlu** * Suleyman Demirel University Medical School, Nuclear Medicine Anabolic Department. Isparta, ** Suleyman Demirel University School of Medicine, General Surgery Anabolic Department. Isparta, ***Suleyman Demirel University School of Medicine, Department of Radiology. Isparta, ****Suleyman Demirel University School of Medicine, Department of Pathology. Despite the fact that breast cancer is a common type of cancer among all women around the world, the mortality rate due to this disease has decreased thanks to early diagnosis and development in treatment. Although mammography and ultrasound are the screening of breast cancer and the methods of imaging used in the diagnosis, both benign and malign injuries can be similar in appearance, causing unnecessary excess of negative biopsy. Using non-invasive methods, it is important to select patients who can benefit from biopsy and reduce the number of biopsy with negative results. For this purpose, various radiocytes are used for breast syntigraphy and positron emission tomography methods. In this study, the findings of breast sintigraphy of the injuries of patients who apply to clinics due to the mass in the breast due to the benign, malign distinction mammography, ultrasound and breast sintigraphy made with Technetium-99m-hexakis-2-methoxy-isobutyl-isonitrile (Tc-99m MIBI) were evaluated retrospectively and aimed at comparing their effectiveness. For this purpose, the results of the biopsy were evaluated by mammography, ultrasound and Tc-99m MIBI breast syntigraphy of 84 observations (the average age is 49.63±11.33 years) with the results of the biopsy. The histopathological examination of fifty-four patients was benign, and 30 patients were detected malignant. The breast syntigraph found 93% sensitivity to malignity, 91% specificity, 83% sensitivity to mammography, 85% specificity and 87% ultrasound sensitivity, 89% specificity. When the three methods are combined, the sensitivity and specificity values are 97 and 96%. It was found to rise. As a result, the use of breast syntigraphy in the detection of palpable breast masses in women with suspicious mammogram and ultrasound, with a high risk of breast cancer, may be recommended in order to reveal the nature of the injury in terms of pre-biopsy malignity. Keywords: breast cancer, Tc-99m MIBI breast syntigraphy, mammography, ultrasound. Abstract Comparison of Tc 99m MIBI scintomammography, mammography and ultrasonography in detection of breast carcinoma However breast carcinoma is the most common neoplasm found among women, improvements in diagnostic and therapeutic methods decreased the mortality rates. Although, mammography and ultrasonography are the most widely used methods for screening and diagnosing breast cancer; images of benign and malignant lesions can be similar in both methods and frequently result in negative biopsies. It is important to reduce the negative result ratio by using non-invasive diagnostic methods. For this purpose scintomammography and PET scanning methods by using different radionuclides can be performed. The aim of this study was to compare the specificity and sensitivity of mammography, ultrasonography and Technetium-99m- hexakis- 2-methoxy-isobutyl-isonitrile (Tc-99m MIBI) scintomammography methods in patients with palpable breast mass in detection of benign and malignant lesions retrospectively. A total of 84 patients (mean age of 49.63±11. 33 years) with palpable breast masses were studied. Mammography, ultrasonography and Tc-99m MIBI scintomammography were performed to all patients. Histopathological examination revealed malignity in 30 patients and benign disease in 54 patients. In the detection of malignancy; sensitivity and specificity of scintomammography, mammography and ultrasonography were 93% and 91%, 83% and 85%, 87% and 89% respectively. Using a combination of three tests, the combined sensitivity and specificity was increased to 97% and 96%. In conclusion scintomammography might be a complementary method for suspicious lesions in mammography and ultrasonography in deciding which lesions require a biopsy. Key words: Breast cancer, Tc-99m MIBI scintomammography, mammography, ultrasonography.

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