Abstract:

Objective: Mammary Paget disease of the breast is a rare form of breast cancer. The study aimed to predict the patients prone to local recurrence, and to find out the answer to the question of who should be a candidate for breast conserving surgery. Material and Methods: Between January 2007 and February 2022, 83 patients who underwent surgery and pathology report diagnosed as Paget’s disease, were analyzed retrospectively. As factors that may affect local recurrence; age, presence of nipple symptoms, mass detection in radiological imaging, type of the surgery, stage, pathological findings of the tumor (histological type, multicentricity, ER, PR, HER2, Ki 67 proliferative index, molecular subtype) were evaluated. Results: Among 83 patients, 32 (38.6%) had ductal carcinoma in situ, and 50 patients (60.2%) had invasive ductal carcinoma, and others had pure Paget disease. Number of the patients who underwent breast-conserving surgery and mastectomy was 19 and 64, respectively. Patients were followed-up for a median time of 73 months. Recurrence was developed in 12 patients (14.5%), 7 of them with local recurrence. Type of the surgery (p=0.001) and young age (p=0.02) were the factor influencing local recurrence. Subgroup analysis was performed among patients undergoing breast-conserving surgery, and age (p=0.07) and absence of nipple symptoms (p=0.07)  were found to affect local recurrence. Conclusion: Although the number of patients is small, it should be kept in mind that local recurrence may be high when breast-conserving surgery is performed in patients with young age

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