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Bu araştırmada bakır oksit nanopartiküllerinin (CuO NP) LD50 konsantrasyonunun etkisinde Galleria mellonella larvalarının orta barsak ve yağ dokularındaki protein, glikojen ve lipit miktarları ile immun sistemde önemli bir parameter olan total hemosit sayısı üzerine etkilerinin belirlenmesi amaçlanmıştır. CuO NP’ nin G. mellonella orta barsak ve yağ dokusundaki protein miktarında istatistiki açıdan fark gözlenmezken, glikojen ve lipit miktarlarında azalma meydana getirdiği tespit edilmiştir. Total hemosit sayısında ise, CuO NP’ nin etkisinde azalma meydana geldiği belirlenmiştir. Sonuç olarak, CuO NP’ nin immun ve metabolik sistemler üzerinde toksik etkilere neden olmaktadır.
In this study, the effect of the concentration of copper oxide nanoparticles (CuO NP) LD50 was aimed at determining the effects of Galleria mellonella larva on the quantities of protein, glycogen and lipid in the mid-belly and fat tissues and the total hemosite number, which is an important parameter in the immune system. CuO NP has been found to cause a reduction in glucogen and lipid levels, while the amount of protein in G. mellonella in the midbelly and fat tissue has not been statistically observed. The total number of hemosites has been determined as a decrease in the effect of CuO NP. As a result, CuO NP causes toxic effects on the immune and metabolic systems.
The aim of this study was to determine the effect of LD50 concentration of copper oxide nanoparticles (CuO NPs) on the amount of protein, glycogen and lipid in the midgut and fat body of Galleria mellonella larvae and total hemocyte count which is an important parameter in the immune system. While CuO NPs were not statistically different protein content in midgut and fat body of G. mellonella, it was found that glycogen and lipid contents were decreased. As for, total hemocyte count decreased when CuO NPs were applied to the diet. In conclusion, it was shown that CuO NPs caused toxic effects on immune and metabolic systems of G. mellonella.
Alan : Fen Bilimleri ve Matematik; Mühendislik
Dergi Türü : Ulusal
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