Özet:

Purpose: This study has studied the relationship between subtypes of schizophrenia, serum nitric oxide (NO) levels and clinical variables. Tools and Methods: 25 healthy control groups with 21 paranoid types, 20 disorganized types, 19 undifferentiated types and 16 residual types of schizophrene patients who apply to the University Hospital Psychiatric Clinic during the study and are treated by bed or foot, diagnosed with schizophrene and in accordance with the study criteria are included in the study. Patients have been applied a sociodemographic and clinical form of information and a short psychiatric evaluation scale. Blood samples were taken from patients and control groups that meets the study criteria between 08.00 - 11.00 in the morning, and serum NO levels were examined with the Griess Reaction. Results: Healthy tests compared to schizophrenia patients; serum NO levels in schizophrenia patients were found higher compared to the control group (p <0.001). The levels of NO in all subgroups of schizophrenia were above controls. No significant correlation has been found between the NO levels in the serums of schizophrenia patients and gender, age, educational status, history of smoking, number of attacks (p >0.05). The result: Our findings suggest that NO is an important molecule in the description of schizophrene etiopathogenesis. Further research is also needed to ensure that NO can be used as a reliable parameter in terms of the clinical course, classification and forecast of the disease.

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