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Amaç: Nötrofil lenfosit oranı (NLO)- Trombosit lenfosit oranı (TLO), eritrosit dağılım değişikliği (RDW) , ortalama trombosit hacmi (OTH) düzeyleri sistemik inflamasyonun bir göstergesi olabileceği ve birçok kardiyovasküler hastalık, maliniteler, romatolojik hastalıklar, enfeksiyon hastalıklarında prognoz ve mortalite ile ilişkili olabileceği son yıllarda yapılan çalışmalarda gösterilmiştir. Bu çalışmanın amacı sistemik kronik inflamatuar bir hastalık olan psoriazis hastalarının sistemik tedavi öncesi ve tedavinin 12. haftasında PAŞİ(Psoriatik Alan Şiddet İndeksi)75 değerine ulaşan hastalarda Lökosit, Nötrofil, Trombosit, NLO, TLO, OTH ve RDW düzeylerindeki değişimi incelemektir. Gereç ve Yöntem: Metotreksat(Mtx)- Siklosporin- Asitretin- dbUVB- İnfiksimab ve Adalimumab tedavisi başlanan kronik plak psoriazisli 60 hastanın hematolojik parametreleri incelenmiştir. Tedavi öncesinde ve tedavinin 12. haftasında PAŞİ75 değerine ulaşan hastaların Lökosit, Nötrofil, Trombosit, NLO, TLO, OTH ve RDW düzeyleri değerlendirilmiştir. Bulgular: Hastaların başlangıç PAŞİ değerleri 16,68±6,5 (Min:6,6,Max:29,6). Tedavi sonrası lökosit, nötrofil ve trombosit ortalamaları tedavi öncesi ortalamalara göre anlamlı derecede düşüş gösterirken (p=0,01; p<0,001; p<0,001), tedavi öncesi ve sonrası lenfosit, OTH ve RDW ortalamaları arasında istatistiksel olarak anlamlı bir farklılık gözlenmemiştir(her biri için p>0,05). Tedavi sonrası NLO ve TLO ortalamaları tedavi öncesi ortalamalara göre istatistiksel olarak düşük bulunmuştur (p=0,043; p=0,009). Tedavi seçeneklerine göre tedavi öncesi ve sonrası ortalamalar karşılaştırıldığında MTX nötrofil, trombosit ve RDW üzerine etkili olmuşken, Asitretin ve Siklosporin nötrofil ve OTH üzerine etkili olmuştur. dbUVB tedavisi verilen hastalarda tedavi öncesi ve tedavi sonrası ortalamalar arasında anlamlı farklılık gözlenmemiştir. Sonuç: NLO ve TLO düzeylerinin tedavi sonrasında anlamlı farklılık göstermesi literatürde yapılan çalışmalarla benzerlik göstermektedir. Çalışmada verilen sistemik tedavi ajanlarından kardiyovasküler risk belirteçleri olarak bilinen hematolojik parametreler üzerine en etkili ilacın Mtx olabileceği düşünülmektedir
Objective: Neutrophil lymphocyte ratio (NLR) - Platelet lymphocyte ratio (PLR), erythrocyte distribution change (RDW), average platelet volume (MPV) levels are an indicator of systemic inflammation. Recent studies have shown that these values are associated with many cardiovascular diseases, malignancies, rheumatic diseases, infectious diseases, prognosis and mortality. The aim of this study was to evaluate the changes in leukocyte, neutrophil, platelet, NLR, PLR, MPV and RDW levels in patients with systemic chronic inflammatory disease psoriasis patients who reached the PASI75 value before the systemic treatment and at the 12th week of treatment. Methods: The hematological parameters of 60 patients with chronic plaque psoriasis who were treated with methotrexate (Mtx)-Cyclosporin-Acitretin-NBUVB-Infliximab and Adalimumab were investigated. Results: The initial PASI values of the patients were 16.68 ± 6.5 (Min: 6.6, Max: 29.6). Post-treatment leukocyte, neutrophil and thrombocyte averages decreased significantly (p = 0.011; p <0.001; p <0.001), but there was no statistically significant difference between pre-treatment and post-treatment lymphocytes, MPV and RDW averages (each p> 0.05). After treatment, NLR and PLR averages were found to be statistically lower than the pre-treatment averages (p = 0.043; p = 0.009). When compared to the pre-and post-treatment average, Mtx was effective on neutrophil, platelet and RDW, Acitretin and cyclosporine were effective on neutrophil and MPV. Significant differences in NLR and PLR levels after treatment are similar to those in the literature. The most effective drug on hematological parameters, known as cardiovascular risk markers, is thought to be Mtx.
Objective: Neutrophil lymphocyte ratio (NLR) – Platelet lymphocyte ratio (PLR), erythrocyte distribution change (RDW), mean platelet volume (MPV) levels are an indicator of systemic inflammation. Recent studies have shown that these values are associated with many cardiovascular diseases, malignancies, rheumatic diseases, infectious diseases, prognosis and mortality. The aim of this study was to evaluate the changes in leukocyte, neutrophil, platelet, NLR, PLR, MPV and RDW levels in patients with systemic chronic inflammatory disease psoriasis patients who reached the PASI75 value before the systemic treatment and at the 12th week of the treatment. Methods: The hematological parameters of 60 patients with chronic plaque psoriasis who were treated with methotrexate (Mtx)-Cyclosporin-Acitretin-NBUVB-Infliximab and Adalimumab were investigated. Results: The initial PASI values of the patients were 16.68 ± 6.5 (Min: 6.6, Max: 29.6). Post-treatment leukocyte, neutrophil and thrombocyte averages decreased significantly (p = 0.011; p <0.001; p <0.001), but there was no statistically significant difference between pretreatment and post-treatment lymphocytes, MPV and RDW averages (each p> 0.05). After treatment, NLR and PLR averages were found to be statistically lower than the pre-treatment averages (p = 0.043; p = 0.009). When compared to the pre-and post-treatment average, Mtx was effective on neutrophil, platelet and RDW, Acitretin and cyclosporine were effective on neutrophil and MPV. Conclusion: Significant differences in NLR and PLR levels after treatment are similar to those in the literature. The most effective drug on hematological parameters, known as cardiovascular risk markers, is thought to be Mtx.
Field : Sağlık Bilimleri
Journal Type : Uluslararası
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