Özet:

Pharmacokinetics deals with all the factors that control this process, including the degree and rate at which a drug enters the body, is distributed, reaches its site of action, exerts its effect and is excreted. It also examines the time-dependent changes in the level of the drug in different compartments during this process. While the primary aim of pharmacokinetics is to determine the variables affecting patient- and drug-related kinetic parameters, the secondary aim is to define the kinetic parameters in the dose-concentration-time relationship. Therefore, the pharmacokinetic parameters of any drug used in emergencies or in special populations are instructive. In the context of COVID-19, understanding the pharmacokinetics of the medications used is crucial in order to achieve optimal therapeutic outcomes. This knowledge helps in determining the appropriate dosage, frequency of administration, and duration of treatment for COVID-19 patients. Pharmacokinetics also plays a role in understanding potential drug-drug interactions and the likelihood of adverse drug reactions. Furthermore, pharmacokinetic studies can aid in the development of new treatment strategies and therapeutic interventions for COVID-19. This article describes the basic pharmacokinetic parameters for favipiravir, remdesivir, lopinavir, ritonavir, chloroquine and hydroxychloroquine, which had to be used in COVID 19 treatment. This study will provide a knowledge base on the pharmacokinetics of various COVID-19 drugs.

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