Özet:

The microbiota is a potential product which experimental data and clinical applications have increased recently. The microbiota shows its effects by changing cell behaviors, particularly those of the stem cells. Understanding of these changes in pathology opens the way for their use in treatment. Changes in intestinal microbiota related to bone diseases which also have a negative impact on patient life quality. In this review, the relationship of microbiota with stem cell and bone was explained based on the literature. Microbiota and bone-related articles of the recent years were reviewed, and the information considered important was collected. When the intestinal microbiota is exposed to various factors, stem cells themselves and the factors they secrete change, which causes hemostasis to deteriorate. The combination of experimental and bioinformatics data shows the possible use of microbiota for the treatment of bone pathologies. Developing technology will make it possible to produce products with significant efficiency and low costs in clinical applications. Using three-dimensional organoid model, it will be much easier to understand the effect of microbiota and similar model can be used for the effectiveness of the treatment. As a result, it may offer new hopes to patients with reduced quality of life.

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