Abstract:

Objective: Non-alcoholic fatty liver disease (NAFLD) is the most common type of chronic liver diseases and it is the hepatic evidence of metabolic syndrome (MtS). But patients with NAFLD have not always MtS, and all patients with MtS have not always NAFLD. In our study, we aimed to investigate the factors related to NAFLD in patients with non-MetS. Materials And Methods: Our study was made at least 400 volunteers from 10 randomly selected Family Health Centers (FHCs) in our city center. Complete blood counts, biochemical tests and hepatobiliary ultrasonography (hUSG) were performed from the individuals. Body mass index (BMI), homeostasis Model Assessment of insulin Resistance (HOMA-IR), fibrosis-4 (FIB-4) and BARD scores were calculated. Results: The prevalence of fatty liver was detected as 33.8% with hUSG. The frequencies of stage 1, 2 and 3 fatty liver were found to be 71.6%, 25.4% and 3.0%, respectively, in those with fatty liver (n=67). In univariate analysis; there were statistically significant differences between those with and without fatty liver individuals for the parameters of age, BMI, waist circumference, diastolic blood pressure, hemoglobin, AST/ALT ratio, ALT, GGT and triglyceride levels. In multivariate logistic regression analysis, BMI (OR: 1,311, p <0.001), hemoglobin (OR: 1,311, p = 0.005), DBP (OR: 1.046, p = 0.044) were shown to be independently associated factors for fatty liver. Conclusion: The frequency of non-alcoholic fatty liver disease is also common in patients with non-MtS. BMI, hemoglobin and DBP are independently associated parameters for NAFLD in those with non-MtS.

Keywords: