Özet:

PR: Purpose: In this play, we aimed at evaluating the effectiveness of the C14 urine respiratory test (CNS) and blood serology test in diagnosing helicobacter pylori (HP) infection in children. Method and means: Repeated abdominal pain, HP positivity C14 and/or serological positivity were identified with a total of 112 children were included in the shooting and the incidents were diagnosed with a thorough histopathological assessment. In 102 cases the diagnosis was confirmed and the treatment was printed. Tests were repeated for all cases after treatment, and the diagnosis was confirmed in 21 with a repeated histopathological examination in 32 positive cases. Results: C14 UNT’s HP sensitivity was 98.2 percent and its specificity was 90 percent. HP diagnosis serology sensitivity is 87. Three specificities were found to be 80%, and in less than seven cases the single negative rate (36%) was significantly increasing. The HP treatment pressure was 79.5%. The post-treatment C14 UNT diagnosed HP with a sensitivity of 95.2 percent and a specificity of 90 percent, although the specificity of serology (64.5 percent) was quite low. The result: Serological assessment in HP diagnosis increases in the early childhood, and in post-treatment followings the positive rate is quite high, therefore, both diagnosis and followings in children are not a good method. C14 UNT HP infection surgeons, especially those who do not justify the problem of conformity, give results in accordance with the histopathological assessment of the child, is a sufficient diagnostic tool in the diagnosis and follow-up after treatment. Keywords: Helicobacter pylori diagnosis tests, C14 urine breathing tests, children EFFICACY OF NON-INVASIVE TESTS IN THE DIAGNOSIS AND POST-TREATMENT FOLLOW-UP OF HELICOBACTER Pylori INFECTION IN PEDIATRIC PATIENTS ABSTRACT: Purpose: Helicobacter pylori (HP) infection is generally acquired in early childhood and is responsible for 15% of cases of peptic ulcus during their lifetime. Furthermore, the recurrence of infection after successful eradication is two times more common in children than in adults. Therefore, widely applicable and sensitive diagnostic tests are required for children. We aimed to evaluate the C14 urea breath test (UBT) and blood serology test for the diagnosis of HP infection in children. Materials and Methods: This study included 112 children with recurrent abdominal pain, in whom positive HP results were obtained with C14 UBT and/or blood serology test. The diagnosis was confirmed histopathologically in 102 patients and they were treated. C14 UBT and/or blood serology test results were positive in 32 of the 102 patients after treatment and the diagnosis was confirmed in 21 of those 32 patients by repeated histopathological analysis. Results: The sensitivity and specificity of C14 UBT were 98.2% and 90%, and the sensitivity and specificity of HP blood serology were 87.3% and 80%, respectively. The blood serology test had a higher false-negative rate (36%) in children under seven years of age for predicting HP infection. HP treatment success was 79.5%. The C14 UBT had higher sensitivity and specificity (95.2% and 90%, respectively), whereas the blood serology had an unacceptable low specificity (64.5%) after treatment. Conclusion: False negative results are higher on evaluation of serology on diagnosis of HP infection in early childhood, and false positive results are higher during follow-up after treatment. Therefore, serology is not a reliable tool for the diagnosis and follow-up in children. C14 UBT results are compatible with histopathologic findings on diagnoses of HP, for cooperative children of all ages; thus it is sufficient for diagnosis and post-treatment follow-up. Keywords: Helicobacter Pylori, Diagnostic Tests, Children