Özet:

Lipid peroxidation leads to deterioration of physiological functions including growth and reproduction as well as the immunity. Some antioxidant enzymes and the exogenous vitamins such as vitamin C and E, and some minerals protect cells against lipid peroxidation. Molecular and cellular effects of vitamin E as an antioxidant are to clean the reactive oxygen species and nitric oxide synthase and to influence cellular structures such as membranes and lipid domains by interacting with specific enzymes and transcription factors. Vitamin E maintains integrity of the long chain polyunsaturated fatty acids that are present in the cell membranes, and retains their bioactivity. Vitamin E is also intensely present in tissues producing the steroid hormone, and protects the very sensitive steroidogenic activities of cytochrome P-450 against lipid peroxidation in these tissues. Stress, disease and the promotion of the immune response may increase the need for nutrients such as vitamins and essential elements. Stress factors such as nutritional imbalances, hot and cold, crowds, noise and transport cause a susceptibility to infectious diseases by weakening the body's defense mechanisms. The need for these vitamins and minerals increases in stress situations. Vitamin E depending on the cell membrane plays an important role in complex cell-cell interactions triggering and regulating the immune responses. Liver and serum are reliable indicators of the vitamin E intake or status. The purpose of this review was to bring together the information and works about the antioxidant properties of vitamin E.

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