Abstract:

In patients with chronic obstructive lungs disease (KOAH), we aimed at assessing changes in the retina nerve fiber layer (RNFL) and optical nerve head (ONH). Tools and Methods: 30 patients with heavy KOAH and 29 healthy people matched in terms of age and gender were taken to study. After a detailed ophthalmic examination, ONH and RNFL thickness measurements were performed with optical coherence tomography (OCT) (Stratus OCT-3). Arterial blood gases (pO2 and PCO2) were measured and respiratory function tests were performed for the evolution of KOAH patients. The OCT parameters are compared between the differences between the two groups using an independent t test, while the Pearson correlation analysis was conducted to assess the correlation between respiratory function tests, arterial blood gas and RNFL thickness parameters. It was statistically considered meaningful that the value of P was less than 0.05. Results: There was no significant difference between KOAH and healthy individuals in terms of optical disk area, container area and rim area (p> 0.05). In KOAH patients, the average and upper RNFL thickness parameters were significantly thicker than the control group (respectively 107.9 ± 5.4 μm and 131.31 ± 13.6 μm) (respectively 114.52 ± 7.7 μm and 141.07 ± 18.2 μm) p= <0.05). There was no meaningful correlation between the PO2 and RSLT thickness (r = -0.22, p = 0.33), a medium meaningful correlation between pCO2 and the upper square RNFL (r = 0.53 and p = 0.017) and a high negative correlation between FEV1 / FVC and the upper square RNFL. (r = -0.76, p = 0.003) The result: an increase in pCO2 and a decrease in FEV1 / FVC indicate increased hypoxia. Peripapils associated with RGC death can be masked by RNFL loss by hypoxic / ischemic-resulted retina and optical disk swelling. The increase in the average RNFL thickness in KOAH patients was considered to be related to increased hypoxia associated retinal payments.