Özet:

Objective: Family hypercholesterolemia is an autosomal dominant hereditary disease that leads to a significant increase in low-dancite lipoprotein cholesterol levels and early age coronary arterial disease and heart-caused death. The disease has heterocygotic and homocygotic forms and its incidences have been as 1:500 and 1:1 000 000 respectively. This disease often occurs due to LDL receptor (the most common), apolipoprotein B (Apo B), proprotein conversion subtilisin/cexin 9 (PCSK9) and LDL receptor adapter protein (LDLRAP) genetic mutations. Family hypercholesterolemic patients do not respond well to lipid-reducing treatments such as statin and therefore lipoprotein afferesis is a distinguished method of treatment. In a 20-year-old female patient diagnosed with homozigot family hypercholesterolemia, we compared the results of two different lipoprotein affection methods, double-filtration plasmaferase (DFPP) and decstrate sulfate column (DSC). 20 sessions of double filtration plasmaferase (DFPP) and 20 sessions of decentralized sulfate column (DSC), a total of 40 sessions were evaluated. In the comparison of the two methods, high-dancity lipoprotein (YDL), leukocyte, platelet, potassium, calcium, prothrombin time and active partial tromboplastin time values changed statistically meaningful. Result: As a result, our study shows that two different methods have different effects on the number of thrombocytes, as the serum electrolyte values, hemostasis standards and leukocytes, the choice of the aferez method would be more appropriate to be done according to the patient’s clinical and laboratory findings.