Abstract:

INTRODUCTION: Obese patients are followed up with periodic laboratory tests. Insulin resistance is also a parameter used in these tests. There is a need for parameters that can determine insulin resistance more easily and practically. The aim of our study is to investigate the discriminative power of triglyceride (Tg) and triglyceride/high-density lipoprotein cholesterol ratio (Tg/HDL) for Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) in our patient population by examining the laboratory findings. METHODS: In this retrospective study, the laboratory data of patients who applied to the Family Medicine Obesity Polyclinic of D�zce University Hospital between April 2018 and April 2019 with the desire to lose weight and/or have healthy lifestyle suggestions were examined. RESULTS: Of the 512 patients included in our study, 66.40% (n=340) were female and 33.59% (n=172) were male. In the examination performed on patients grouped according to their Body Mass Index (BMI), Total cholesterol, HDL, Low-density lipoprotein (LDL), Tg, HOMA-IR, Insulin and Tg/HDL ratios were significantly different between the groups. The cut-off value in the ROC analysis of the Tg/HDL parameter between patients with and without insulin resistance was found to be 2.29 with 66% sensitivity and 55% specificity (AUC: 0.634, p<0.001). In Spearman's correlation analysis of Tg/HDL and HOMA-IR, both parameters were found to have a statistically significant correlation (r: 0.248; p< 0.000). DISCUSSION AND CONCLUSION: The significant relationship between the high Tg/HDL ratio and HOMA-IR detected in the results of our study shows that the Tg/HDL ratio can be used as a practical tool to evaluate insulin resistance in obese patients.

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