Abstract:

Introduction: Although the place of endoplasmic reticulum (ER) stress is known in obesity patophysiology, the role of stress in cardiovascular diseases (ER) caused by obesity is not exactly known. Our study was carried out in order to study the effects of resveratrol, a natural polyphenolic compound, on the ER-stress induced by palmitic acid (PA), a free fatty acid in the H9c2 cell series. Tools and Methods: H9c2 cell series is incubated with PA in various concentrations and time intervals, providing ER-stress formation. Using various concentrations of resveratrol, the ER-stress pathway and the apoptotic pathway that this pathway is triggered have been studied. Results: PA has activated the ER-stress path depending on dose and time. This path has also caused the activation of an apoptotic path. While resveratrol reduces the ER-stress induced by PA, it has also inhibited apoptosis. However, while PA causes increased cell oxidative stress, resveratrol has shown an antioxidant to be effective. Results: Our findings have shown that resveratrol is effective in reducing the ER stress induced by PA in H9c2 cells and in the inhibition of apoptosis.

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