Özet:

Objective The relationship between chronic inflammation and psychiatric disorders has been evaluated in previous studies. Neutrophil-lymphocyte ratio (NLR), platelet- lymphocyte ratio (PLR), and mean platelet volume (MPV) appear to be new markers for the evaluation of systemic inflammatory response. In this study, it was aimed to evaluate the levels of NLR, PLR and MPV biomarkers in patients with major depressive disorder (MDD) by comparing them with healthy controls, and also investigate the relationship between biomarkers and MDD. Material and Method This cross-sectional study was carried out from July 15, 2020 to May 15, 2021. The study was conducted with 92 patients with diagnosed MDD and 72 healthy controls who agreed to participate. The sociodemographic data form and SCID-5/CV form were filled out for each participant through face-to-face interviews with all participants. Additionally, Hamilton Depression Scale was applied to the patient group to determine the severity of MDB. Results Patients with MDD and healthy controls were compared in terms of the mean scores of NLR, PLR and MPV, and no statistically significant difference was found between the groups (p>0.05). Additionally, in the patient group, there was no statistically significant difference between the levels of depression severity (mild, moderate, severe) in terms of the mean scores of NLR, PLR, and MPV (p>0.05). Conclusion This is the first study to evaluate NLR, PLR and MPV biomarkers simultaneously in MDD patients by comparing them with healthy controls. In this study, it was found that there was no significant relationship between NLR, PLR and MPV levels and MDD. Additionally, it was determined that there was no relationship between the severity of depression and the aforementioned markers. Further studies investigating these and another biomarkers with prospective and larger studies will provide more insight into the inflammatory process in MDD.

Anahtar Kelimeler: