Abstract:

Purpose: The study in our hospital between January 2007 and September 2017 was aimed at diagnosing, monitoring and reverse assessment of 10 patients diagnosed with neonatal diabetes mellitus (NDM).  Tools and Methods: In the study between January 2007 and September 2017, SBU Ankara Child Health and Diseases Hematology Oncology Education Research Hospital received NDM diagnosis, followed and treated 10 patients. Patients received treatment immediately and after the application, demographic data and laboratory findings were examined.  Results: Two of the patients (%20) were male, 8 (%80) were angry and the average diagnosed age was 12.5 days (CDA 4-68.25 days). Three (30%) of the patients had no relatives in their parents, 7 (70%) of the patients had a first-degree cousin marriage. The most frequently applied complaints were hyperglycemia found in the examinations due to increased urine quantity, impurity, vomiting and low birth weight. In the genetic examination of three (30%) patients, mutations were identified; homozigot mutations in the SLC2A2 gene, homozigot mutations in the IPF1 gene, and homozigot divisions in exon 3 in the INSR gene. One of our patients was diagnosed with Wollcott Rallison syndrome and the other with Fanconi Bickel syndrome. At the time of application, nine patients were given insulin infusion and fluid treatment, and one patient was given subcutaneous (sc) insulin treatment. After patients' hyperglycemia was controlled, sc was transferred to insulin (short or medium-effective) treatment. One patient was tested with insulin pump treatment, we had no patients receiving oral antidiabetic treatment. Result: NDM should be taken into account in cases of hyperglycemia that require insulin treatment for more than two weeks in the first 6 months of life. All diagnosed patients should be genetically examined and the treatment options should be re-evaluated according to the outcome. All patients, including patients with temporary NDM diagnosis, should be monitored for a long time. Neonatal DM is a major disease that can threaten life and requires more research on the frequency, clinical course and treatment of the disease.

Keywords: