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Amaç: Bu çalışmada, kronik hepatit B tanılı hastalarda serum HBV DNA düzeyleri,Hbeag durumları, biyokimyasal parametreler ile karaciğer inflamasyonu ve fibrozisin şiddeti arasındaki ilişkiyi araştırmak amaçlanmıştır. Gereç ve Yöntemler: Kliniğimizde 01.01.2015 ile 01.05.2018 tarihleri arasında kronik hepatit B tanısı ile karaciğer biyopsisi yapılan 231 hasta çalışmaya alındı. Tüm hastalar Hbeag pozitif ve negatif olma durumuna göre iki gruba ayrıldı. Bu hastalarda serum HBV-DNA düzeyleri, biyokimyasal parametreler ile karaciğer inflamasyonu ve fibrozisin şiddeti arasındaki ilişki araştırıldı. Öncesinde tedavi alan veya HBV-DNA düzeyi <2000 IU/ml olan hastalar çalışmaya dahil edilmedi. Bulgular: Çalışma grubunu oluşturan 231 hastanın 129(%55,8)’u erkek, 102(%44,2)’si kadındı ve yaş ortalamaları 42,7± 11,7 idi. Bu hastaların 198 (%85,7)’i AntiHBe pozitif, 33(%14,3)’üHbeag pozitif idi. Hbeag pozitif hasta grubunun ortalama HBV-DNA düzeyi 143.027.706 IU/ml ve Anti HBe pozitif hasta grubunun ortalama HBV-DNA düzeyi 14.054.684 IU/ml idi. Hasta gruplarının karaciğer biyopsi sonuçları ISHAK skorlarına göre karşılaştırıldığında; Fibrozis evresi (p=0,745) ve Hepatik Aktivite İndeksi (p=0,645) arasında istatistiksel olarak anlamlı bir fark saptanmadı. Sonuç: Sonuç olarak çalışmamızda Hbeag pozitif hastalarda ALT ve HBV-DNA düzeyleri; anti HBe pozitif hastalarda ise yaş ortalaması ve bilinen hepatit yılı anlamlı yüksek bulundu. Vakaların antiHBe/ Hbeag durumları ile Fibrozis ve HAİ skorları ile diğer biyokimyasal değerleri arasında istatistiksel anlamlılık saptanmadı.
Purpose: In this study, chronic hepatitis B diagnosed patients intended to investigate the relationship between serum HBV DNA levels,Hbeag conditions, biochemical parameters and hepatic inflammation and the severity of fibrosis. In our clinic from 01.01.2015 to 01.05.2018 231 patients were diagnosed with chronic hepatitis B and hepatic biopsy were taken to study. All patients were divided into two groups according to the status of Hbeag positive and negative. In these patients, the relationship between serum HBV-DNA levels, biochemical parameters and hepatic inflammation and the severity of fibrosis was studied. Patients who were previously treated or who had a HBV-DNA level <2000 IU/ml were not included in the study. Results: 129 (55.8%) of the 231 patients in the study group were male and 102 (44.2%) female, with an average age of 42.7±11.7. 198 of these patients (85.7 percent) were antiHBe positive, 33 (14.3 percent) were Hbeag positive. The average HBV-DNA level in the Hbeag positive group was 143.027.706 IU/ml and the average HBV-DNA level in the Anti-HBe positive group was 14.054.684 IU/ml. When compared the results of the liver biopsy of the patient groups according to the ISHAK scores, there was no statistically meaningful difference between the phase of fibrosis (p=0,745) and the hepatic activity index (p=0,645). The result: in our study, the ALT and HBV-DNA levels in Hbeag positive patients were significantly high, while in anti-Hbe positive patients the average age and known hepatitis year were significantly high. There is no statistical significance between the anti-HBe/Hbeag cases and fibrosis and HAI scores and other biochemical values.
Aim: In this study, we aimed to retrospectively evaluate the biopsy results, biochemical and serological parameters of patients with chronic hepatitis B followed up in our clinic. Material and Methods: A total of 231 patients with chronic hepatitis B who underwent liver biopsy in our clinic between 01.01.2015 and 01.05.2018 were included in the study. All patients were divided into two groups according toHBeAg positive and negative status. Serum HBV-DNA levels, biochemical parameters, liver inflammation and the severity of fibrosis were investigated. Patients who received prior therapy or had HBV-DNA levels <2000 IU/ml were not included in the study. Results: Of the 231 patients in the study group, 129 (55.8%) were male and 102 (44.2%) were female, and the mean age was 42.7±11.7. Of these patients, 198 (85.7%) were anti-HBe positive and 33 (14.3%) were HBeAg positive. The mean HBV-DNA level of the HBeAg positive patient group was 143.027.706 IU/ml and the mean HBV-DNA level of anti-HBe positive patient group was 14.054.684 IU/ml. ALT (p=0,044) and HBV-DNA values (p=0.037) were significantly higher in HBeAg positive group than in the other group. Liver biopsy results of the patient groups were compared according to the ISHAK scores; there was no statistically significant difference between fibrosis stage (p=0.745) and hepatic activity index (p=0.645). Conclusion: In conclusion, in our study, ALT and HBV-DNA levels were found to be significantly higher in HBeAg positive patients and mean age and known hepatitis year were significantly higher in anti HBe po
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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