Abstract:

In December 2019, a large number of research has been carried out on the Coronavirus Disease-2019 (COVID-19) which soon affected the entire world and caused the deaths of approximately four million people, starting in Wuhan, China. The evolutionary process of the parasites, which are as old as human history, is often overlooked, although they are common and high mortality infectious factors. However, recent studies show that the immune change caused by parasitic infections affects the course of viral diseases. Because serious respiratory coronavirus-2 (SARS-CoV-2) and Plasmodium jointly use the CD147 receptor to enter the cell and both factors have similarities in the antigen determinants offered with MHC; the developing immunity against parasitic infections is believed to be able to protect the body against SARS-CoV-2 infection, which can explain the cause of low COVID-19 incidence in countries where the sputum is endemic. The cytocin storm, which is responsible for mortality in COVID-19 infection, causes the immune system to activate in the direction of Th1. On the other hand, helminth infections that activate the immune system in the direction of Th2 can reduce mortality by preventing the cytokine storm. The relationship between COVID-19 and parasites is not limited only to changes in the immune system. It has been shown that from the beginning of the pandemic all interests are directed to COVID-19 and the stop in the fight against parasitic infections will lead to an increase in the incidence of many factors, such as scratch, leishmaniasis, cystosomiasis and soil-transmitted helminths. Therefore, additional measures should be taken immediately from where it is left to fight again and expanded to cover the whole world.

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