Abstract:

Early stages of the diagnosis of glottic larynx cancer and curative radiotherapy were aimed at the reverse assessment of the treatment results and prognostic factors in the cases applied. In our clinic between 1993 and 2010, radiotherapy was applied, biopsy and histopathological diagnosis of cancer were confirmed and no pre-RT treatment was applied in early stages (T1-2N0) Glothic larynx cancer 73 cases were studied backward. The data of all the incidents were updated and the effects of the patient, tumor and treatment parameters on local-regional control and survival were studied. The average age of patients is 60 (37-83) and 69 are male and 4 are female. The distribution according to the levels is in the form of 41 (56.2%) T1a, 8 (10.9% T1b, 24 (32.9% T2). The patient was median 66 Gy (58,5-72) external radiotherapy. Depending on radiotherapy, in 1 incidence (1.4% grade 3-4 early and late laringeal swelling developed, in no other incidence except this occurrence, grade 3-4 early and late toxicity was not seen. Median 73 (5-209) in a monthly follow-up of a total of 10 (13.7%) patients have locally-regional nickel detected, no distant metastasis has been detected in any case. The patient’s 5-year local-regional control, disease-specific survival and overall survival rates are 85, 92% and 78% respectively. From the examined factors, the "interruption of treatment for 5 days or more" significantly reduces local-regional control and the disease-specific survival (rendered to p=0,008, p=0,036), the "pre-treatment period of noise reduction less than 5 months" only significantly reduces local-regional control (p=0,036) was found. As a result, early stages of glottic larynx cancer are an effective form of treatment with high local control rates as a primary treatment. The intervals given to radiotherapy for various reasons are a prognostic factor that negatively affects local-regional control and the disease-specific survival. Treatment should be avoided as much as possible.

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