Abstract:

Purpose: Thin intestinal adenocarcinoma is a rare tumor and the data related to the prognosis is limited. In this study, we aimed at evaluating clinic pathological characteristics and prognostic factors in patients with thin intestinal adenocarcinoma. Method: Twenty two patients were evaluated. Clinical pathological characteristics and treatment approaches were recorded retrospectively. Caplan-Meier and Cox regression analyses were used to evaluate general survival and prognostic factors. Results: The primary output places of the tumor were duodenum (50%), jejunum (31.8%), and ileum (18.2%). The number of de novo metastatic patients was 11 (50%). The most common metastatic areas were peritonus (45%), liver (41) and lymph nodes (18%). The average survival period was 19.9 months (7.3-32,5). One and two-year survival rates were 65.9% and 39% respectively. In metastatic patients, the first-stage chemotherapy response rate (full or partial response) was 46.2%. In multiple variable analyses, surgery (p=0,024) and diagnosed age (p=0,017) were identified as statistically meaningful prognostic factors for overall survival. However, the primary tumor area (p=0,106), de novo metastatic disease (p=0,323) and the number of metastatic areas (p=0,086) were not statistically meaningful. Result: Patients with thin intestinal adenocarcinoma were diagnosed with a frequently advanced disease and the prognosis of the disease was poor. We found that the removal of the primary tumor improves the survival and that being older than 60 years of age during the diagnosis is a negative prognostic factor.

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