Özet:

Purpose: The purpose of this study is to evaluate the levels of fluid in which the developmental endothelial locus-1 (Del-1) and lymphocyte function-associated antigen-1 (LFA-1) are regulatory cytocins in the tight adhesion stage of the neutrophile adhesion path in individuals with different disturbance paterns and periodontal disease. Tools and Methods:Selçuk University, 42 individuals who apply to the Department of Periodontology and Dentistry of the Faculty of Dentistry were included in the study. The clinical and radiological examination resulted in the clinical records of individuals included in the Grade B periodontitis(n=23) and Grade C periodontitis (n=19), such as the sonding cell depth (SCD), clinical attachment level (KAS), plaque index (PI), gingival index (GI), sonding bleeding percentage (SKY) and sputum and dental fluid (DOS) samples were collected. The levels of Del-1 and LFA-1 citocin were assessed by the ELISA method. For statistical analysis, the Mann-Whitney U test was used in group comparisons.p<0.05 was determined as a statistical meaning level. Results::When clinical parameters were evaluated; the SCD, PI and SKY values were significantly high, the CAS and GI values were significantly high in Grade C periodontitis group. The ELISA analysis found no significant differences between the LFA-1 and Del-1 sputum and DOS levels.The inflammatory LFA-1 sputum and DOS levels tended to be higher in Grade C, where individuals with relatively more severe periodontal disease were found.The LFA-1 antogonist found that the Del-1 sputum levels tended to be higher in Grade B and the DOS Del-1 levels tended to be higher in Grade C. This study shows that the levels of Del-1 and LFA-1, which play a role in the transendotelial migration of neutrophiles, may provide information about the severity of the periodontal disease but requires further studies to determine the role of these citocins in the periodontal disease. Keywords:Periodontitis,Sitokin,Periodontitis,Periodontitis

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