Abstract:

In the period of the first trimester screening test, between the 11-14 weeks of pregnancy, we wanted to investigate whether this disease affects the test indicators in patients with the diagnosis of severe hyperemesis gravidarum (HEG) that affects both nutrition and metabolic negative effects and loses weight. Tools and methods: Retrospective in a reverse center, the first trimester screening test was performed between the 11-14 weeks of pregnancy and the control groups consisting of healthy pregnancies without pregnancy nausea were compared in the same weeks with the study group with severe pregnancy vomiting. Screening test indicators such as fetal angularity (NT), head popo distance (CRL), human coronic gonadotropin (hCG) and pregnancy-related plasma protein-A (PAPP-A) were statistically compared between both groups. Results: In total of 108 patients with severe HEG, 1264 pregnancies that meet the control group criteria were assessed. In both groups, there was no statistically significant difference in terms of age, pregnancy week, body mass index and pregnancy. When it comes to birth results, the baby was similar in terms of birth weights and gender. Both groups were similar in terms of NT, CRL, free ß-hCG values and hCG MoM (multiple of median) values (p = 0.844, p = 0.770, p = 0.777, p = 0.634, respectively). In the serious HEG group, both the PAPP-A levels and the PAPP-A MoM values were statistically significantly lower compared to the control group (p = 0.044, p = 0.001). The result: there is no significant impact on serious HEG, NT, CRL and free ß-hCG. But it is noted that PAPP-A has changed its values. Therefore, it can be said that the results of the first trimester screening test in pregnancies with severe HEG may be affected. There is a need for extensive research on the subject. Keywords: Hyperemesis gravidarum; hCG, PAPP-A; First trimester screening test ABSTRACT Objective: We wanted to investigate whether hyperemesis gravidarum affects first trimester screening test markers in patients who were followed up and treated with severe hyperemesis gravidarum (HEG), which affects pregnancy both in terms of nutritionally and metabolically. Materials and methods: A retrospective, case control study was performed in a tertiary center. The study group included the pregnant women who had severe pregnancy vomiting and the control group included healthy pregnant women who did not have pregnancy vomiting. Screening test markers such as fetal nuchal translucency, crown-rump-lenght (CRL), human chorionic gonadotropin (hCG) and pregnancy-related plasma protein-A (PAPP-A) were compared statistically between the two groups. Results: A total of 108 patients with HEG levels were evaluated for the study group and 1264 pregnant women who met the control group criteria were evaluated. There was no statistically significant difference for maternal age, gestational age, body mass index and pregnancy in both groups. The birth results were similar in terms of birth weight and fetal gender. Both groups were similar in terms of nuchal translucency, CRL, free ß-hCG values and hCG MoM values (p = 0.844, p = 0.770, p = 0.777, p = 0.634, respectively). In the level HEG group, both PAPP-A levels and PAPP-A MoM values were statistically lower than the control group (p = 0.044, p = 0.001). Conclusion: Severe HEG has no significant effect on fetal nuchal translucency, CRL and free ß-hCG. However, PAPP-A values could change due to the level HEG. Therefore, it can be said that the results of the first trimester screening test performed in pregnant women with HEG may be affected. Extensive research is needed on the subject. Keywords: Hyperemesis gravidarum; hCG; PAPP-A; First trimester screening test