Özet:

It is known that chronic stress increases behaviors similar to depression. Geraniol is a natural monoterpend known for its neuromodulator and antidepressant effects. This study is designed to investigate the possible effects of geraniol on the chronic restriction of stress and depression in rats. Method and method: 21 adult female rats were used in the study. Mouse stress restriction was applied for 5 hours a day for 3 weeks. Geraniol was administered via oral gathering 100 mg/kg. Following stress and medication applications, anxiety, compulsory swimming tests and depression-like behaviors were evaluated with an open space test. The rats were then disqualified in the hypocampus. The levels of acetylcholine (ACh) and acetylcholineesterase (AChE) were determined by the ELISA method in the hypochampal tissue homogenates. Results: Stress exposure did not significantly affect an anxiety-like behavior but warned depression-like behavior parameters in compulsory swimming tests. Geraniol has been found to significantly reduce the increased stress-related immobility time (p<0.05). Furthermore, stress exposure and geraniol application were not observed significantly affecting the hypomkampal ACh levels (p>0.05). On the other hand, chronic stress has significantly reduced the AChE levels (p<0.05). Geraniol therapy has not been found to significantly change the AChE levels (p>0.05). Conclusion: When discussed together, our findings showed that restrictive stress causes depression-like behavior in rats, while geraniol therapy has antidepressant-like effects. However, we recommend the study of the molecular mechanism of the antidepressant-like effect of geraniol with advanced studies.

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