Özet:

The aim. To analyse the peculiarities of the epidemiological situation on lymphogranulomatosis in the country during 2012-2018. Materials and methods. The studies used data from the National Cancer Registry for 2012-2018. Historical, analytical, comparative, systemic, logical, hypothetical-deductive, mathematical-statistical, as well as methods of epidemiological studies were used. Results. It was established that morbidity and mortality of the adult and children's population from lymphogranulomatosis, expressed in absolute terms during 2012-2018 in Ukraine decreased. Thus, the number of patients with lymphogranulomatosis in 2012 compared with the data in 2018 decreased by 26.9 %, and mortality – by 41.2 %, among children – by 37.7 % and 25.0 %. All absolute indicators were complex in terms of the nature of the changes, with peak values in 2015 and 2018 (incidence among adults), as well as in 2016 (mortality among adults) and in 2015 (incidence of children). At the same time, not a single indicator reached or exceeded the value of the 2012, with the exception of data on the incidence of children with lymphogranulomatosis in 2015 (an increase of 11.8 % compared with the previous 2014). It is gratifying that after 2015, the incidence rates of children with Hodgkin's disease have steadily declined. It was proved that women prevailed taken together indicators of morbidity (53.4 %), and in the mortality structure, on the contrary, the proportion ( %) of women was less (43.0 %). Among the children's contingent of patients, there were more men (53.0 %). According to the analysis of the relative incidence rates among men, it was found that their average value (2.29 per 100 thousand of the population in Ukraine) did not exceed the corresponding data of world epidemiology (2.3 per 100 thousand of the population of indicators) for lymphogranulomatosis. Among women, the average incidence rate (2.46 per 100 thousand of the population) significantly exceeded the corresponding world indicators (1.9 per 100 thousand of the population). The average value of the indicators of relative mortality from lymphogranulomatosis, which we calculated for 2012-2018 amounted to 0.69 for men and 0.47 for women per 100 thousand people against world figures of 0.4 and 0.3, respectively. Thus, we can conclude that the level of male mortality in Ukraine from lymphogranulomatosis was 1.7 times higher than the corresponding world indicators and 1.6 times higher for the female population. Conclusions. From 2012 to 2018, Ukraine was able to reduce morbidity and mortality rates significantly, expressed in absolute data. At the same time, with regard to relative indicators, the fact of an increase in the incidence among women, as well as mortality from lymphogranulomatosis among adult patients causes our concern. This allows us to conclude that it is necessary to implement early diagnosis programs and chemotherapy regimens further, which can increase the 5-year survival of patients, as well as achieve stable and long-term remission in these patients. Author Biographies Marta Matushchak, Higher State Educational Institution of Ukraine «Bukovinian State Medical University» Teatralna sq., 2, Chernivtsi, Ukraine, 58002 Assistant Department of Pharmaceutical Botany and Pharmacognosy

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