Abstract:

Purpose: In this study, we studied the impact of L-Arginine on hemodynamic, biochemical, histopathological changes in the rabbit models created by renal ischemistry. Methods: In our study; 40 white new zellans were used with rabbits. The rabbits were divided into two groups: the control group (n=20) and the L-argin group (n=20). Ear and femoral arteries were monitored by canulating. From the contralateral femoral artery, the aortic oxygen catheters were swallowed by extending to the left subclavian artery distaline and 30 minutes (min) oxygen was applied. All examiners were given 4 mL/kg/hour NaCl infusion during the oxygen and in the first 60 minutes of the reperfusion. In the group of L-arginine; during the first 60 minutes of oclusion and reperfusion, 3 mg/kg/hour of L-arginine was applied in the form of infusion from the ear venus. Blood samples for biochemical parameters (glucose, lactate, hematocrit, urethra, creatine) were taken during pre-skemic period, in the 20th minute of the reperfusion and immediately before the sacredness (48 hours). Both renal tissues were histopathological examinations. Tuberculary epithelial cell flatness, brushing side loss, cytoplasmic vacualization, cell necrosis, tubular lumen obstruction, histopathological scores were carried out taking into account. All animals were sacrificed 48 hours after the treatment. Results: In our study; in the L-arginine group, hemodynamic according to the control group and 48 hours BUN, a significant difference was found in terms of the creatin values (p<0,05). In the histopathological study, the control group’s score average was 3.2±0,89, the L-Argin group’s score average was 2.60±0,68 (p<0,05) (p=0,022). The result: it can be said that the administration of L-Argin reduces the damage to the reperfusion of renal ischemia, especially its histopathological effects. (JAREM 2016; 6: 24-30)

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