Özet:

Non-alcoholic fatty liver disease (NAFLD) defined as fatty accumulation in liver without alcohol consumption. NAFLD is known as the most common chronic liver disease worldwide. NAFLD can cause serious diseases such as cirrhosis and hepatocellular cancer (HCC). We aimed to evaluate retrospectively 220 liver biopsy proven patients with NAFLD in this study. A total of 220 patients diagnosed with NAFLD by liver biopsy followed in the gastroenterology outpatient clinic of Demiroğlu Bilim University Faculty of Medicine between 2010-2019 were included in the study. Demographic data (age, gender, height, weight and body mass index), biochemical laboratory parameters and biopsy results were scanned and recorded retrospectively from hospital information system and files of patients. The mean age of the patients was 34.14 ± 6.72 and 60% of the patients were male and 40% were female. Mean liver steatosis percentage was similar in male and female patients (p: 0.41). The mean BMI of the patients was 27.32 ± 3.02, the mean liver steatosis percentage was 12.1 ± 8.68% and the mean Homeostatic Model of Assessment-Insulin Resistance (HOMA-IR) value was 2.64. There was a positive correlation between liver steatosis and BMI, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamaglutamyl transferase, total cholesterol, triglyceride, creatinine and HOMA-IR, but no correlation was found between liver steatosis and age, urea and bilirubin. In our study, it was observed that NAFLD can be seen in young and middle-aged, non-obese individuals, and BMI and insulin resistance may be associated with NAFLD in this patient group. In addition, liver enzymes were found to be associated with NAFLD even if they were in the normal range. More reliable data can be obtained with new and more extensive studies.

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